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Targeting breast cancer stem cells as a therapeutic strategy


Richard Clarkson is senior lecturer of cancer research in the School of Biosciences (Cardiff University, Cardiff, UK) and is an inaugural member of the European Cancer Stem Cell Research Institute (Cardiff, UK), a purpose-built research facility looking at the causes of and new therapies for cancer with a specific emphasis on cancer stem cells. He received his PhD from the Faculty of Medicine, University of Manchester (Manchester, UK) and carried out research at the University of Queensland (Queensland, Australia) and the University of Edinburgh (Edinburgh, UK), before taking up consecutive fellowships at Cambridge University (Cambridge, UK). In 2005, he moved to Cardiff (UK) to take up a lectureship in translational cancer research. His expertise is in cell and molecular biology – particularly the genetic regulation of cell fate and tissue (cellular) architecture in mammalian tissues. His move from Cambridge to Cardiff coincided with a shift in research emphasis towards the etiology and molecular targeting of cancer, taking what he had learned about the genes that regulate mammary tissue homeostasis in the mouse to the pathology of breast cancer, and today he runs a team of researchers that focus on two key drivers of metastatic breast cancer: cell migration and cancer stem cells.

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