Spotlight on organoids in oncology

Organoids have unearthed new avenues for the development of novel preclinical cancer models, which are essential for the efficient translation of basic cancer research into novel treatment regimens for patients with cancer. Join us as we explore how they can be utilized as an alternative model for cancer research.

 

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Spotlight on tumor mutation burden

We have witnessed great advancements for cancer over the past few years, namely immunotherapy. Despite this success, the use of these drugs remains imprecise, with a limited ability to identify patients who will benefit from treatment. Tumor mutational burden (TMB) is promising as a predictive biomarker and could potentially lead the way for immuno-oncology to enter an era of precision medicine.

 

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Spotlight on biosimilars in oncology

Over the coming weeks on Oncology Central we will be carrying out a Spotlight event exploring the field of biosimilars in oncology. Join us as we look further into their development, evaluate the potential benefits alongside regulatory challenges and see whether there are sufficient resources available to clinicians who are considering adopting biosimilars.

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Spotlight on interventional oncology

Much of the available literature discussing the topic defines interventional oncology as the fourth pillar of cancer therapy, where it stands alongside medical, surgical and radiation oncology. Over the coming weeks on Oncology Central we will be carrying out a Spotlight event looking further into the field of interventional oncology. This Spotlight will take an overarching view and aim to review this discipline from benchside to bedside.

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Spotlight on cancer and the immune system

Cancer immunotherapy is arguably one of the biggest developments and one of hottest topic within oncology. This Spotlight reviews the intricacies of how cancer cells and immune cells interact, look at the escape mechanisms that cancers employ to evade an antitumor immune response and explore the story behind some of the novel immunotherapy agents that have been developed to reverse this immune evasion.

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Spotlight on circulating tumor cells

As has been proven, cancer does not simply consist of one type of cell; rather tumors can be made up of a heterogeneous collection of cells with varying phenotypes. It has been proposed that only a small subpopulation of the cells making up a tumor hold any tumorigenic potential – namely cancer stem cells (CSCs). The CSC model proposes that these cells renew and sustain the tumor in a background of nontumorigenic cells, driving therapy resistance, recurrence and enabling metastatic spread.

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Spotlight on cancer stem cells

As has been proven, cancer does not simply consist of one type of cell; rather tumors can be made up of a heterogeneous collection of cells with varying phenotypes. It has been proposed that only a small subpopulation of the cells making up a tumor hold any tumorigenic potential – namely cancer stem cells (CSCs). The CSC model proposes that these cells renew and sustain the tumor in a background of nontumorigenic cells, driving therapy resistance, recurrence and enabling metastatic spread.

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