Secretory breast carcinoma (SBC) is a rare tumor that is even rare in male adults. To our knowledge, only 28 previous male cases of SBC have been reported. The present case of SBC has the longest symptom duration (40 years) in male until now. The clinical features and treatment of male SBC is similar with female SBC. When compared with the usual type of male breast cancer, patients with male secretory breast cancer are much younger, and have a lower rate of estrogen/progesterone hormone receptor positivity. Modified radical mastectomy has been favored in all female SBC, male SBC and usual type of male breast cancer. ETV6–NTRK3 fusion gene is a specific genetic alteration in SBC.
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