Organ-on-a-chip model uncovers crucial tumor microenvironment interactions
Researchers from the Texas A&M University (TX, USA) have developed a ovarian tumor microenvironment chip (OTME-Chip). The chip comprises of a platelet-perfused tumor microenvironment and which recapitulates platelet extravasation and its consequences.
“We are creating a platform technology using the organ-on-a-chip approach where tumor biology can be advanced, and new drugs can be identified by recreating the platelet-tumor and platelet-tumor-drug interactions under the influence of flow, supporting blood vessels and the extracellular matrix,” commented Abhishek Jain, lead researcher and assistant professor in the Department of Biomedical Engineering at the Texas A&M University.
The model the team created has successfully revealed the mechanism through which platelets promote the metastasis of ovarian tumors, highlighting a novel drug target to increase the success of chemotherapies.
Find our more by reading the full news story on our sister site BioTechniques.
Sources: www.biotechniques.com/cancer-research/sartorius_advcmsptl_exploring-platelet-induced-metastasis-with-organ-on-a-chip-technology/; www.sciencedaily.com/releases/2021/07/210723154527.htm
