A novel oncolytic virus could induce long-term antitumor immunity against colon cancer

City of Hope (CA, USA) have recently published the preclinical results of their oncolytic virus therapy for colon cancer. The virus has been shown to increase PD-L1 expression in mouse models, leading to T-cell recruitment, cell death and potentially, long-term T-cell immunity. The efficacy of immune checkpoint inhibitors can still vary significantly between patients and the tumor biology behind this variation is still not fully understood. The oncolytic viral therapy developed by City of Hope (known as CF33) aimed to improve the immune system’s ability to recognize and destroy tumor cells more effectively. Yuman Fong (City of Hope) explained "CF33,...