Highly mutated cancers in evolutionary battle with immune system

Researchers at The Institute of Cancer Research (London, UK) have discovered that hyper-mutant tumors, often seen in stomach and gullet cancers, are able to rapidly evolve strategies to disguise themselves from the immune system. The results of the study, published in Nature Communications, could help to inform the development of new immunotherapies in order to maximize their impact.“Cancer evolution is the biggest challenge in cancer research and treatment today – and deepening our understanding of how tumors evolve in response to treatment is absolutely key to finding ways of overcoming drug resistance,” commented Paul Workman from the Institute of Cancer...