Enhancing immunotherapy by targeting cellular metabolism

Written by Ryan Gilroy (Future Science Group)

Tumor microenvironment

A research team from UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine (both PA, USA) detail how cancer cells can manipulate the tumor microenvironment (TME) to both starve killer CD8 T cells of and provide regulatory T cells (Treg) with nutrients in order to evade immune attack, and how this provides a basis for enhancing immunotherapy by targeting cellular metabolism. The paper published today in Nature, detailed how tumors can take up vital nutrients from the TME to deprive killer T cells whilst also providing lactate to the TME to attract Treg, which shield the tumor from...

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