Chemotherapy resistance: microRNA could play a key role in bile duct cancer

Researchers from The Institute of Cancer Research (London, UK) have discovered that a molecule of microRNA, MIR1249, plays an important role in the resistance of cancer cells against chemotherapy within bile duct cancers. Currently, there are limited treatment options available for patients with bile duct cancer. The new findings, recently published in Hepatology, could help develop novel cancer drugs to target MIR1249 and make chemotherapy more effective at treating bile duct cancer.“It’s remarkable how such a tiny piece of RNA can play such a significant role in rewiring cancer cells so that they can resist chemotherapy,” commented Chiara Braconi (Institute...