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Beyond biologics: is there a role for systemic cytotoxic chemotherapy in neuroendocrine tumors?

Neuroendocrine tumors (NETs) are a group of biologically and clinically heterogeneous neoplasms that have varying degrees of responsiveness to systemic and targeted therapies. With recent advances in therapeutics, a number of biologic therapies have been incorporated into the management of NETs. In this review, we discuss the role of cytotoxic chemotherapy in the management of NETs with an overview of past and present clinical trials, current treatment guidelines and future directions.

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