A recent study lead by researchers at Massachusetts General Hospital (MA, USA) has highlighted a novel mechanism behind resistance to angiogenesis inhibitors.
Researchers have discovered the ability of cancer cells to force the fibroblasts in a tumor to mimic a viral infection, allowing tumors to spread and respond to attack with greater efficacy.
Researchers have demonstrated a previously undefined role of histone deacetylase 11 (HDAC11), in regulating T-cell effector functions.
In this article, the authors provide an up-to-date review of all reported genomic aberrations in the eight most common pediatric solid tumors with whole-exome sequencing or whole-genome sequencing data.
This prospective, noninterventional study evaluates the effectiveness, tolerability, safety and quality of life following 450 patients with mRCC starting either on pazopanib as first-line therapy or third-line everolimus plus/minus lenvatinib following nivolumab.
This paper provides an analytical validation for the 12-gene molecular assay. This test provides a clinical score that combines molecular information from genes within the tumor with clinical information to determine whether a breast cancer is at high or low risk of recurrence.