TALAPRO-2: talazoparib plus enzalutamide in metastatic castration-resistant prostate cancer

PARP inhibitors in combination with androgen receptor-targeted therapy have demonstrated potential in the treatment of metastatic castration-resistant prostate cancer (mCRPC). A recent clinical trial protocol, published in Future Oncology, described the design and rationale of the multinational, Phase III, two-part TALAPRO-2 study comparing talazoparib plus enzalutamide versus placebo plus enzalutamide as a first-line treatment for patients with mCRPC with or without DNA damage response alterations.

In this video, Neeraj Agarwal (University of Utah, UT, USA) on behalf of his co-authors discusses their recent publication ‘Talazoparib plus enzalutamide in metastatic castration-resistant prostate cancer: TALAPRO-2 Phase III study design’.

Original publication:

Agarwal N, Azad A, Shore ND et al. Talazoparib plus enzalutamide in metastatic castration-resistant prostate cancer: TALAPRO-2 Phase III study design. Future Oncol. 18(4), 425–436 (2022).

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The opinions expressed in this interview are those of the interviewee and do not necessarily reflect the views of Oncology Central or Future Science Group.

This content is part of our Publication In Focus on TALAPRO-2: view more content from this feature by clicking here.