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Prognostic factors in chronic lymphocytic leukemia: a conceptual approach


Prognostic assessment is an essential component in the management of patients with chronic lymphocytic leukemia. Prognostic factors (e.g., clinical stage, lymphocyte doubling time and IGHV mutational status/ZAP70 expression), allow predicting time to disease progression and need of therapy and also provide a rough estimate of the overall survival. The most important predictor of survival in patients requiring intervention is response to therapy and its degree, patients with undetectable minimal residual disease following therapy having a much better outcome than those with an inferior response. Given the increasing number of treatment modalities for CLL, the identification of predictive factors is important. Unfortunately, with the only exception of del(17p)/TP53 mutations that predict a poor response to purine analogs-based therapy and del(11q) that correlates with inferior response to fludarabine given as single agent, there are not reliable predictors of response. Well-conducted studies aimed at identifying prognostic and, particularly, predictive factors are needed. New prognostic and predictive parameters should demonstrate superiority over already well validated markers and be helpful in the management of patients with CLL.

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