Novel treatment strategy could prevent tumors from developing chemotherapy resistance in mice

Written by Caitlin Killen, Future Science group

A study led by the Spanish National Cancer Research Centre (CNIO; Madrid, Spain) in collaboration with Weill Cornell Medicine Center (NY, USA) and Pfizer Inc. (NY, USA) has proposed a potential strategy to prevent the development of chemotherapy resistance in pancreatic cancer patients. Recently published in Cancer Cell, the research has demonstrated the efficacy of administering CDK4 and CDK6 inhibitors subsequent to chemotherapy for the prevention of further tumor growth. CDK4/6 are cell-cycle kinases that are dysregulated in some cancers, resulting in uncontrolled cell growth. CDK4/6 inhibitors have been approved in combination with hormone therapy for the treatment of advanced...

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