Novel immunogenic cell injury strategy could eliminate tumors in mice
Closeup of female hand with IV drip infusion in treatment session at hospital, copy space
Researchers at the Massachusetts Institute of Technology (MIT; MA, USA) have developed a novel strategy that stimulates stronger T cell activity against tumors by damaging tumor cells ex vivo, allowing them to initiate distress signals in vivo. Combined with immune checkpoint inhibitors, the strategy eliminated tumors completely in 40% of mice studied. The study, published recently in Science Signaling, combined the T cell reactivation effect of immune checkpoint inhibitors with the immunostimulatory effect of immunogenic cell death to create a stronger, targeted response against tumors. The strategy could allow for the application of immunotherapy to a broader range of cancers...