Have you seen our new ‘How I treat…’ features? Become a member (it’s free!) and discover the latest advice from fellow clinicians here >>>

Novel immunogenic cell injury strategy could eliminate tumors in mice

Written by Louis Gautier, Future Science Group

Immunogenic cell injury

Researchers at the Massachusetts Institute of Technology (MIT; MA, USA) have developed a novel strategy that stimulates stronger T cell activity against tumors by damaging tumor cells ex vivo, allowing them to initiate distress signals in vivo. Combined with immune checkpoint inhibitors, the strategy eliminated tumors completely in 40% of mice studied. The study, published recently in Science Signaling, combined the T cell reactivation effect of immune checkpoint inhibitors with the immunostimulatory effect of immunogenic cell death to create a stronger, targeted response against tumors. The strategy could allow for the application of immunotherapy to a broader range of cancers...

To view this content, please register now for access

It's completely free