New drug target discovered to prevent metastasis in pancreatic cancer

Written by Louis Gautier, Future Science Group

A recent investigation at Sanford Burnham Prebys Medical Discovery Institute (CA, USA) has yielded novel insights into molecular drivers of metastasis in pancreatic cancer. The team discovered the protein biomarker, PPP1R1B, significantly reduced metastasis in mice and could be a promising target for future therapy. Published recently in Gastroenterology, the results present a significant step forward in tackling the highly aggressive and deadly disease. Pancreatic cancer is often detected symptomatically at an advanced stage and the 5-year survival rates of those with metastatic disease is fewer than 10%, compared with nearly 40% if the cancer remains localized. “Our study uncovers...

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