How do gut microorganisms influence the immune system and cancer treatment?

Written by Balkees Abderrahman (University of Texas MD Anderson Cancer Center, TX, USA, and the University of Leeds, West Yorkshire, UK)

The microbiota has been shown to produce metabolites that have local and systemic effects on cancer onset, progression, and therapy responses and toxicity. In this editorial from Balkees Abderrahman, find out about the relationship between the gut microbiome and cancer, including how the microbiome can be modulated to enhance the effects of cancer therapeutics. The microbiome (or microbiota) is an ecological niche of commensal, symbiotic, and pathogenic microorganisms (bacteria, archaea, protists, fungi and viruses), known as the “super organism”, which influences the immunologic, hormonal, and metabolic hemostasis of their host (human or non-human) [1-3]. The human microbiome contains a metagenome exceeding our...

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