How can we predict response to immune checkpoint inhibitors in mice?

Researchers from Massachusetts General Hospital and Harvard Medical School (both MA, USA) have developed an approach to identify potential clinical markers that may indicate which patients will respond to immune checkpoint inhibitors (ICIs). Recently published in the Proceedings of the National Academy of Sciences, the study involved an approach that implanted breast cancer tumors into mice and then treated the animals with ICIs. "We first developed a resection and response bilateral tumor model in which we put one breast tumor in each side of the mouse breast. We then remove one tumor to evaluate the tumor microenvironment and we monitor...