Developing therapeutics to target oncogenic drivers of solid tumors in children

Cancer Grand Challenges is a trailblazing research funding initiative, which aims to take on some of the toughest challenges in oncology by uniting a global network of cancer researchers. In this feature, we speak with team PROTECT project lead Stefan Pfister (Hopp Children’s Cancer Center Heidelberg, Germany) to find out how his team are using protein degradation strategies to target previously undruggable drivers of children’s cancers and how this could transform treatment options for pediatric tumors. What are the key oncoprotein drivers of childhood cancers? Transcription factor fusion proteins or other transcription factor abnormalities are frequently pediatric-specific cancer drivers. There...