Characteristics and risk factors for early-onset metachronous colorectal adenoma
Abstract
Aim: Compare risk factors for early-onset-metachronous colorectal adenoma (EOMCA) among individuals <50 versus ≥50 years. Materials & methods: Descriptive statistics compared clinical/demographic characteristics for individuals <50 and ≥50. Logistic regression estimated associations between demographic and clinical attributes and EOMCA. Results: N = A total of 1623 participants. Individuals <50 years (vs ≥50) had higher smoking rates, greater intake of red meat, monounsaturated fatty acids, total fat and less sleep, sedentary behavior, aspirin intake, supplemental calcium use and higher mean energy-adjusted dietary inflammatory index (E-DII™) score (pro-inflammatory diet) (all p ≤ 0.001). Odds of EOMCA were higher among smokers and participants reporting previous polyp(s). Overall odds of EOMCA were lower among individuals <50. Conclusion: History of previous polyps and smoking were risk factors for EOMCA. Lifestyle factors require further research.
