Beyond monoclonal gammopathy of undetermined significance, clinical spectrum of immunoglobulin M gammopathy

Our partnered journal The International Journal of Hematologic Oncology has recently published a case series of three distinct cases of IgM monoclonal gammopathy with diagnosis of type 1 cryoglobulinemia, type 2 cryoglobulinemia, and rare presentation of Waldenström macroglobulinemia with Bing–Neel syndrome. Abstract Immunoglobulin M monoclonal gammopathy is detected in Waldenström macroglobulinemia (WM), a rare lymphoplasmacytic lymphoma with serum immunoglobulin M. We report three rare presentations with focus on diagnostic and management challenges of type I cryoglobulinemia, type II cryoglobulinemia, and Bing–Neel syndrome. In approximately 10% of WM cases, macroglobulins can precipitate to cryoglobulins. Type I and II cryoglobulinemia, representing 10–15%...