BCL-2 inhibition in acute myeloid leukemia: resistance and combinations

This paper from Expert Review of Hematology explores the impact that venetoclax has had on acute myeloid leukemia treatment. The article also reviews associated challenges such as varying patient responses and emerging resistance mechanisms, which highlight the need for personalized combination therapies and further clinical research in this space. Access the full article Introduction The introduction of venetoclax has revolutionized the treatment landscape of acute myeloid leukemia, offering new therapeutic opportunities. However, the clinical response to venetoclax varies significantly between patients, with many experiencing limited duration of response. Areas covered Identified resistance mechanisms include both intrinsic and acquired resistance to...