A plain language summary of patients in the CHRYSALIS study with EGFR exon 20 insertion-mutated NSCLC who received amivantamab
A Plain Language Summary of Publication, which was recently published in Future Oncology, describes the CHRYSALIS study for those who wish to know more about NSCLC with EGFR exon 20 insertion mutations.
Abstract
What is this summary about?
This is a plain language summary of an article published in the Journal of Clinical Oncology in 2021. It describes the first results from 1 group of patients in the Phase I CHRYSALIS study with epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutations. This part of the CHRYSALIS study (called cohort D) investigated the bispecific antibody amivantamab in patients with non-small-cell lung cancer (NSCLC) with an EGFR ex20ins mutation. EGFR mutations are one of the most common causes of NSCLC tumors, with EGFR ex20ins mutations being more common among people of Asian descent. Patients who took part in this study had cancer that could not be removed by surgery, and whose cancer had worsened after receiving other forms of treatment, such as chemotherapy. Typically, patients with this type of mutation have few treatment options after chemotherapy or do not experience treatment response with commonly used therapies that target EGFR.
What were the results?
The CHRYSALIS study took place between May 27, 2016, and June 8, 2020, in select hospitals in the USA, Japan and South Korea. In cohort D, amivantamab showed promising results, with an overall response rate of 40%. This means that 4 of every 10 patients in CHRYSALIS cohort D had tumors that shrank or were no longer measurable. Amivantamab exhibited a tolerable safety profile consistent with on-target inhibition of EGFR and MET pathways.
In association with Janssen Oncology