A novel three-dimensional high-throughput screening approach allows researchers to identify inducers of a mutant KRAS selective lethal phenotype.
Browsing: tumor biology
Quantitative translational modeling to facilitate preclinical to clinical efficacy & toxicity translation in oncology
This article describes a mathematical modeling framework to facilitate the prediction of clinical efficacy and toxicity of investigational antineoplastic agents.
In a landmark genetics study, a multi-institutional group of researchers have uncovered three distinct evolutionary paths for kidney cancer, allowing them to determine whether a tumor will be aggressive.
Researchers have demonstrated that in mice genetically predetermined to have colorectal cancer, Viagra significantly reduces the risk of the disease.
To mark International Women’s Day we recently spoke with Victoria Sanz Moreno from Kings College London (UK) to find out what inspired her to get into cancer research.
Investigators have discovered why Huntington’s disease is so toxic to cancer cells and are harnessing it as a novel approach to treat cancer.
A PGE2-receptor type-4 inhibitor, termed E7046, has demonstrated promising clinical activity in a Phase I trial of patients with advanced solid tumors.
To mark World Cancer Day we are highlighting the most significant advancements in modern oncology to investigate how the field has advanced and what hurdles still need to be overcome.
A novel viral-gene therapy could improve results from breast reconstruction surgery after cancer treatment by helping healthy tissue protect itself from radiotherapy damage.
Researchers have discovered that anti-PD-1/PD-L1 therapies are highly effective in patients with desmoplastic melanoma, challenging previous assumptions.