Ewing sarcoma (EwS) is a highly aggressive malignant tumor of bone or soft tissue, mostly affecting adolescents and young adults . Metastasis is a catastrophic event in the clinical course of EwS patients . Although prevention of metastasis appears key for improving outcome, no specific therapeutic strategies have yet been implemented in routine clinical protocols specifically blocking EwS progression. Here, we summarize the current knowledge on several aspects that we consider being essential for a better biological understanding of EwS progression, and propose next steps for future research and therapeutic intervention.
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