Repurposing drugs in your medicine cabinet: untapped opportunities for cancer therapy?

Many forms of cancer lack efficacious treatments, despite continuing advances in our understanding of molecular biology, and the development of precisely targeted agents that exploit relevant drivers and pathways of malignancy. To date the effectiveness of most tumor cell-focused molecularly targeted agents, in terms of event free and overall survival appears to be modest [1]. What is more, these new drugs come with a high price tag as companies seek to recoup development costs and to generate a return on investment (in part a consequence of a high attrition rate in oncological drug development, high regulatory burdens and expensive clinical trial costs) [2].

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