Androgen receptor structure offers new insights for prostate cancer treatment

A team of researchers from the Baylor College of Medicine have investigated the 3D structure of the androgen receptor, a primary driver of prostate cancer. The findings from the study, recently published in Molecular Cell could suggest new treatment designs for prostate cancer in the future.Co-corresponding author Dr Bert O’Malley (Baylor College of Medicine) commented: “To treat this cancer effectively, we need to better understand how the androgen receptor works. In this study, we reveal for the first time the complete 3D structure of the active, full-length androgen receptor-coactivator complex as it interacts with DNA.” Using cryo-electron microscopy, the researchers...