Optimising Dose to Tumour with Selective Internal Radiation Therapy (SIRT)

Selective Internal Radiation Therapy (SIRT) or transarterial radioembolisation (TARE) involves injection of 90Y-containing microspheres through the hepatic artery into liver tumours. This therapy combines two approaches: irradiation of tumour tissue and embolisation of blood vessels.

Two different types of 90Y microspheres currently exist in the market: glass microspheres (TheraSphere™, BTG) and resin microspheres (SIR-Spheres®, Sirtex).4-6 Aside from resin microspheres having a slightly larger diameter compared to glass microspheres (20–60 μm vs. 20–30 μm) the main difference is the activity per microsphere at calibration: 50 Bq for resin and 2500 Bq for glass.

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