Aim: The purpose of this study was to investigate the correlation between fecal incontinence and quality of life after low anterior resection and long-term follow-up. Methods: For 72 patients with coloanal or low colorectal anastomosis, the quality of life was determined by the European Organisation for Research and Treatment of Cancer (EORTC) questionnaires C-30 and CR-38. The Vaizey score was used for assessment of fecal incontinence. Results: The risk of fecal incontinence significantly increased with a lower level of anastomosis (p < 0.001). The QLQ CR-38 did not discern differences between patients. The OLQ C-30 only found significantly worse social and role function in patients with coloanal anastomosis. There was a weak correlation between fecal incontinence and quality of life only. Conclusion: Determination of quality of life by EORTC QLQ C-30 and CR-38 cannot replace measurement of functional outcome. Severity of fecal incontinence and quality of life should be determined separately for assessment of functional outcome after low anterior resection.