A team of scientists have bound gene editing CRISPR/Cas9 to nucleotide aptamers to selectively target and edit osteosarcoma cancer cells.
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Among other criteria, in this research article from Future Science OA, the authors validated the Gynecological Cancer Intergroup CA125 progression criteria in an ovarian cancer population regarding sensitivity, specificity, positive predictive value and negative predictive value.
Researchers from the University of Georgia (GA, USA) have suggested the cause behind an increase in breast cancer genetic testing in the US in 2013.
The largest genomics study of chordoma to date has discovered a gene mutation possessed by some patients which is a target for existing drugs known as PI3K inhibitors. Previously, these drugs have not been considered for chordoma.
Researchers from the University of Southern California Roski Eye Institute (CA, USA) have derived genetic information from retinoblastoma tumors without removing the eye.
How could the epigenome serve as a promising therapeutic target in reversing cancer-associated muscle catabolism? Find out in this commentary article from Epigenomics.
Researchers at Sanford-Burnham Prebys Medical Discovery Institute (CA, USA) demonstrate that changes in alternative splicing are implicated in cancer.
A novel syndrome in the FANCM gene caused by biallelic mutations predisposes the body to tumors and rejection to chemotherapy.
What pathways modulated by DNMT3B isoforms and which could regulate cell proliferation and other biological mechanisms in breast cancer cell lines? Find out, in this research article from Epigenomics.