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0 Preoperative treatment for locally advanced rectal cancer: is there enough evidence to define the preferable radiotherapy schedule?

Worldwide earlier diagnosis and improvement in treatment modalities gained a huge amelioration of clinical results for locally advanced rectal cancer (i.e., T3, T4 and/or nodal positive clinical presentations) in the last three decades, but still there is urgency for further improvement; moreover, there are some controversies regarding the preferable clinical management. Radiotherapy currently plays a central role in primary treatment [1,2].

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