Oncology Central

Dual-action virus targets both cancer cells and associated fibroblasts

Carcinoma-killing virus enadenotucirev is being used to specifically deliver a T-cell engaging protein that targets tumor-associated cells, whilst having no effect on normal, unassociated cells in the rest of the body.

Cancer-associated fibroblasts are healthy cells that are tricked by their neighboring cancerous cells to provide tumors with growth factors and nutrients, and to protect them from the immune system. For the first time, researchers have specifically targeted these cells, by equipping a virus with a bispecific protein. Current methods of targeting these fibroblasts cannot differentiate between ‘helper’ fibroblasts and unrelated fibroblasts in other areas of the body, causing toxicity and unwanted side effects.

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