Original Publication Date: 20 August, 2018
Publication / Source: CNS Oncology
Authors: Gregory F Guzauskas, Marc Salzberg & Bruce CM Wang
Aim: To estimate the mean lifetime survival benefit, an essential component of health economic evaluations in oncology, of adding tumor treating fields (TTFields) to maintenance temozolomide (TMZ) for newly diagnosed glioblastoma patients. Methods: We integrated EF-14 trial data with glioblastoma epidemiology data. The model provided for an evidence-based approach to estimate lifetime survival for the material number of EF-14 trial patients still alive at 5 years. Results & conclusion: Patients treated with TTFields and TMZ had an incremental mean lifetime survival of 1.8 years (TTFields/TMZ: 4.2 vs TMZ alone: 2.4). Patients alive at year 2 after starting TTFields had a 20.7% probability of surviving to year 10. The results presented here provide the required incremental survival benefit necessary for a future assessment of the incremental cost–effectiveness of TTFields.
Glioblastoma is the most common and aggressive primary brain malignancy. The estimated incidence of glioblastoma is 12,390 new cases each year in the United States. The age at diagnosis is in the mid-60s in epidemiology reports and in the mid-50s in clinical trial populations.[2-4] The disease progresses rapidly without advanced treatment; however, clinical and epidemiological literature has consistently indicated that a small subset of patients survives to 5, 10 and 15 years [5-7].