Oncology Central

Key genes and regulatory networks involved in the initiation, progression and invasion of colorectal cancer



Aim: Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC. Results: The results of gene expression profiles were integrated with protein–protein interaction networks, and topologically analyzed. The most important regulatory genes (e.g., CDK1UBCESR1 and ATXN1) and signaling pathways (e.g., Wnt, MAPK and JAK-STAT) in CRC initiation, progression and metastasis were identified. In vitro analysis confirmed some in silico findings. Conclusion: Our study introduces functional hub genes, subnetworks, prioritizes signaling pathways and novel biomarkers in CRC that may guide further development of targeted therapy programs.

Restricted Content / Members Only

You cannot view this content because It is available to members only. Please or Register to view this area.





News Headlines

Leave A Comment

Please wait...

Would you like access to more immuno-oncology content?

Register with Oncology Central to find out the latest news, opinions and journal articles published in the oncology field by leading experts.