Authors: Jade Parker, Editor
Researchers have discovered 110 genes linked to an increased risk of breast cancer. Findings from the study, conducted at The Institute of Cancer Research (London, UK), were recently published in Nature Communications.
Genome-wide association studies (GWAS) have identified approximately 100 breast cancer risk loci, to now translate these findings into an understanding of the mechanisms that influence disease risk requires identification of the genes or non-coding RNAs that mediate these associations.
This study, which is the most comprehensive study ever to unpick the genetics of the disease, utilized a technique termed Capture Hi-C to study interactions between different regions of the genome.