Oncology Central

Endogenous virus expression could help predict RCC responsiveness to immune checkpoint therapy

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Recently at the 2018 ASCO-SIC Clinical immune-oncology symposium (CA, USA, 25-27 January) a panel discussed the science presented in a new study (Abstract 104) entitled ‘Expression of endogenous retroviruses and response to immune checkpoint therapy in renal cell cancer (RCC)’.

“Increasing mutational burden is generally associated with increasing responses” to immune checkpoint inhibition, explained the lead author on the study, Shridar Ganesan from the Rutgers Cancer Institute of New Jersey (RJ, USA).  “However, there are some exceptions”, these include malignancies such as Merkel cell carcinoma, as well as RCC.

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