Oncology Central

Oncolytic virotherapy before surgery sensitizes TNBC to checkpoint therapy

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Researchers have demonstrated that neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer (TNBC) to immune checkpoint therapy. The findings were recently published in Science Translational Medicine.

TNBC is a notoriously aggressive and difficult-to-treat type of breast cancer for which treatment options are few and associated with severe toxicities. Utilizing a therapeutic mouse model that mimics the metastatic spread of breast cancer after surgery, researchers have demonstrated that oncolytic virus therapy in combination with immune checkpoint blockade cured 60–90% of the mice, compared

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