Oncology Central

Lymphoma and the immune system: genetic link discovered

A major new study reports that individuals who inherit genetic changes, which alter the function of their immune system, are at increased risk of developing Hodgkin lymphoma. Many of the DNA changes identified seemed to affect the function of the immune system. Three in particular had previously been associated with autoimmune diseases such as multiple sclerosis, rheumatoid arthritis or lupus. These findings could highlight new ways of diagnosing, treating and preventing Hodgkin lymphoma.

The study published in Nature Communications, is the largest of its kind for Hodgkin lymphoma. Hodgkin lymphoma can normally be successfully treated with first-line therapies; however there is a need for new treatments for those whom first-line treatment has failed.

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