Original Publication Date: 1 September, 2017
Publication / Source: Nanomedicine
Authors: Fatemeh Movahedi , Li Li , Wenyi Gu & Zhi Ping Xu
Initially emerging as a widely used clinical antiparasitic drug, albendazole (ABZ) has been increasingly recognized as an effective anticancer agent due to its outstanding advantage, in other words, low toxicity to normal cells but high effectiveness against parasites and some tumors. The major challenge is its poor water solubility and subsequently low bioavailability. This article thus first reviews the brief achievements in using ABZ to treat parasites and cancers, and summarizes the basic mechanisms of action of ABZ.