Original Publication Date: 1 November, 2016
Publication / Source: Epigenomics
Authors: Bernard Thienpont, Eva Galle, & Diether Lambrechts
Oncogenesis occurs through the acquisition of mutations and the subsequent selection of those that confer growth advantages. Apart from these genetic changes, tumors are also epigenetically distinct from their tissue of origin, as they frequently display a global DNA hypomethylation and a focal hypermethylation at tumor suppressor gene promoters. Similar to mutations, such epigenetic aberrations can inactivate associated genes and contribute to oncogenesis. The source of these epigenetic alterations is, however, often unknown.