Original Publication Date: 1 March, 2017
Publication / Source: Immunotherapy
Authors: Hiroyuki Tada, Tsunao Kishida, Hitoshi Fujiwara et al
Aim: The somatic cell reprogramming technology was applied to a novel and promising ex vivo immune-gene therapy strategy for cancer. To establish a novel ex vivo cytokine gene therapy of cancer using the somatic cell reprogramming procedures. Methods: Mouse fibroblasts were converted into chondrocytes and subsequently transduced with IL-12 gene. The resultant IL-12 induced chondrogenic cells were irradiated with x-ray and inoculated into mice bearing CT26 colon cancer.