Oncology Central

Glycinated fullerenes for tamoxifen intracellular delivery with improved anticancer activity and pharmacokinetics

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Aim: Glycine-tethered C60-fullerenes were conjugated with N-desmethyl tamoxifen and evaluated for drug delivery benefits. Materials & methods: C60-fullerenes were functionalized with glycine, and N-desmethyl tamoxifen was conjugated, employing a linker and characterized for micromeritics, drug loading, drug release and evaluated for cancer cell toxicity, cellular uptake and pharmacokinetics. Results:

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