Oncology Central

Comparison of the molecular profile of brain metastases from colorectal cancer and corresponding primary tumors


Aim: Little is known about molecular biology of brain metastasis (BM) from colorectal cancer and its concordance with matched primary tumors. Materials & methods: We identified 56 consecutive colorectal cancer patients who underwent neurosurgical resection of BM. Tumor samples were tested for KRAS, NRAS, BRAF and PIK3CA. The molecular profile of the brain lesion was compared with the corresponding primary tumor.

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