Original Publication Date: 1 November, 2016
Publication / Source: International Journal of Endocrine Oncology
Authors: Haroun Jedidi, Liliya Rostomyan, lulia Potorac, Frédérique Depierreux-Lahaye, Patrick Petrossians & Albert Beckers
Familial pituitary adenomas account for approximately 5–8% of all pituitary adenomas. Besides the adenomas occurring as part of syndromic entities that group several endocrine or nonendocrine disorders (multiple endocrine neoplasia type 1 or 4, Carney complex and McCune–Albright syndrome), 2–3% of familial pituitary adenomas fit into the familial isolated pituitary adenomas (FIPA) syndrome, an autosomal dominant condition with incomplete penetrance. About 20% of FIPA cases are due to mutations in the AIP gene and have distinct clinical characteristics.