Original Publication Date: 1 December, 2016
Publication / Source: Melanoma Management
Authors: Ahmad A Tarhini, Hussein Tawbi & Walter J Storkus
Melanoma remains a significant health concern worldwide, with disease incidence continuing to rise over the past four decades. In the USA alone in 2016, the American Cancer Society estimates that 76,380 new cases of melanoma will be diagnosed, with 10,130 patients succumbing to this disease. Although early stages of the disease are surgically curable and adjuvant therapy of high-risk disease is moderately effective in preventing recurrence, advanced-stage, metastatic melanoma has historically exhibited poor durable response rates to existing therapy options and high disease-associated fatality rates.