Original Publication Date: 4 July, 2016
Publication / Source: Immunotherapy
Authors: Daniels-Wells TR, Penichet ML
The transferrin receptor 1 (TfR1), also known as CD71, is a homodimeric protein that is a key regulator of cellular iron homeostasis and proliferation [1,2]. It is a type II transmembrane protein with a large extracellular domain. This receptor interacts with iron-loaded transferrin (Tf) to import iron into the cell. The TfR1/Tf/iron complex is taken up through constitutive clathrin-mediated endocytosis. Due to the decrease in pH in intracellular vesicles, iron is released from Tf and the TfR1/Tf complex is recycled back to the cell surface where Tf dissociates from the receptor.