Original Publication Date: 23 September, 2016
Publication / Source: Nanomedicine
Authors: Tuettenberg A, Steinbrink K, Schuppan D
Macrophages, myeloid-derived suppressor cells and tolerogenic dendritic cells are central players of a heterogeneous myeloid cell population, with the ability to suppress innate and adaptive immune responses and thus to promote tumor growth. Their influx and local proliferation are mainly induced by the cancers themselves, and their numbers in the tumor microenvironment and the peripheral blood correlate with decreased survival.