Oncology Central

40 years in melanoma research: an interview with Meenhard Herlyn about his career in research and the outlook for the field


Meenhard Herlyn speaks to Sebastian Dennis-Beron, Commissioning Editor:

Dr Meenhard Herlyn is Caspar Wistar Professor for Melanoma Research and Director of the Melanoma Research Center at The Wistar Institute in Philadelphia, as well as Founding President of the Society for Melanoma Research. He has been a cancer researcher since arriving at Wistar in 1976 and has worked in melanoma research since 1977. Current major efforts include the ability to model the microenvironment of normal and diseased human tissue through 3D artificial skin, providing his laboratory with a unique insight into cancer research. His laboratory also seeks to further define the various signaling pathways that work in cancer cells in order to discover new opportunities to inhibit cancer growth through targeted therapeutics. Since therapy is increasingly guided by the genetic aberrations in tumors, Dr Herlyn and colleagues are developing combinations of compounds that take into account the genetic signature of tumors, with the specific goal of individualized cancer therapy. Another major effort of his laboratory is the study of therapy resistance and tumor dormancy.

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