Original Publication Date: 14 July, 2016
Publication / Source: Biomarkers in Medicine
Authors: Lan J, Li J, Ju X, Zhou Y, Qi Y, Ren Y, Zou H, Wang L, Li M, Pang L
Tumors may arise from a small subset of cancer cells that are capable of self-renewal, unlimited proliferation and tumorigenicity; such cells are termed cancer stem cells (CSCs) . CSCs have been identified and isolated from tumors and tumor-derived cell lines, including melanoma  and brain , breast  and lung cancers . It is widely accepted that angiogenesis is involved in the growth and hematogenous spread of tumors . Cancer invasion and metastasis involves multiple complex steps and involves a variety of molecules. Angiogenesis, which enables the supply of blood and nutrients for tumor growth, is an important step in cancer invasion and metastasis [6,7]. According to the CSC hypothesis, CSCs play a critical role in maintaining the capacity for malignant proliferation, invasion, metastasis and recurrence of the tumor . CSCs may induce cancer metastasis through multiple pathways and support tumor progression by promoting angiogenesis . Therefore, accumulating evidence indicates that CSCs play a predominant role in neovascularization during tumor growth.