Oncology Central

Relationship between microvessel density and cancer stem cells in tumor angiogenesis: a meta-analysis


Tumors may arise from a small subset of cancer cells that are capable of self-renewal, unlimited proliferation and tumorigenicity; such cells are termed cancer stem cells (CSCs) [1]. CSCs have been identified and isolated from tumors and tumor-derived cell lines, including melanoma [2] and brain [3], breast [4] and lung cancers [5]. It is widely accepted that angiogenesis is involved in the growth and hematogenous spread of tumors [1]. Cancer invasion and metastasis involves multiple complex steps and involves a variety of molecules. Angiogenesis, which enables the supply of blood and nutrients for tumor growth, is an important step in cancer invasion and metastasis [6,7]. According to the CSC hypothesis, CSCs play a critical role in maintaining the capacity for malignant proliferation, invasion, metastasis and recurrence of the tumor [8]. CSCs may induce cancer metastasis through multiple pathways and support tumor progression by promoting angiogenesis [9]. Therefore, accumulating evidence indicates that CSCs play a predominant role in neovascularization during tumor growth.

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