Oncology Central

Circular RNA expression in basal cell carcinoma


Basal cell carcinoma (BCC), is a semimalignant, slow growing, locally infiltrating and the most frequently occurring tumor in humans [1,2]. Although first described in 1900 by Krompecher as ‘carcinoma epitheliale adenoides’, the molecular pathogenesis is today still not completely understood [3]. Mutations of the PTCH1 receptor as part of the SHH signal transduction pathway were demonstrated in 70% of the BCCs in the form of loss-of-function mutations [4–6]. In 10% of all BCCs, gain-of-function mutations of SMOH protein that is naturally present on the cell membrane have been demonstrated [7].

Restricted Content / Members Only

You cannot view this content because It is available to members only. Please or Register to view this area.




News Headlines

Leave A Comment

Please wait...

Would you like access to more immuno-oncology content?

Register with Oncology Central to find out the latest news, opinions and journal articles published in the oncology field by leading experts.