Original Publication Date: 1 May, 2016
Publication / Source: Biomarkers in Medicine
Authors: Fan Pu, Shenghui Xue & Jenny J Yang
Precision molecular imaging addresses major medical gaps including the early detection of small lesion and biomarker expression, especially for high-risk patients, and monitoring the dynamic changes of biomarkers during disease progression and upon therapeutic treatment. One of the major challenges in achieving precision medicine is developing our capabilities to select patients with genetic and phenotypic heterogeneity while monitoring treatment responses. Current golden standard of histological analysis coupled with biopsy has many limitations, such as invasiveness, significant sampling errors especially for small lesions and risks of tumor peritoneal seeding .